ࡱ> M bjbjd&d& QLGiLGi2 2 8,0( Ld d d U"U"U"///////$2K5\0U"3""U"U"U"0d d 0&&&U"d d /&U"/&&6+,d ƗJ"z,/000,5#,58,5,U"U"&U"U"U"U"U"00%dU"U"U"0U"U"U"U"5U"U"U"U"U"U"U"U"U"2 X :   Form MSC1 Risk assessment for the decontamination of a microbiological safety cabinet Guidance The microbiological safety cabinet (MSC) is an essential tool in many microbiological laboratories. All classes of MSC can, if used correctly, provide a good level of protection to the user whilst handling biologically hazardous samples. Class II and III cabinets can also provide a good level of microbiological protection to the work by ensuring that HEPA filtered air passes over the sample. The nature of the work undertaken in these cabinets necessitates that for both unplanned spillage situations and for planned maintenance and testing (see Table 1) appropriate disinfection procedures of the cabinet be developed. These will range from the use of topical chemical disinfectants, either wiped or sprayed, to the gassing of the cabinet with formaldehyde. Table 1. Frequency of MSC performance tests to be carried out by a competent engineer* Containment Level 2Containment Level 36 monthlyAirflow testIn-use KI operator protection factor test (OPFT) HEPA filter integrity test12 monthlyOPFT HEPA filter integrity testIn-use KI operator protection factor test (OPFT) HEPA filter integrity test*This is in addition to the daily, weekly and monthly checks that must be made by the user. HEPA filters must be replaced by an engineer as and when users identify via their own airflow tests or indicator dials that the cabinet is not performing correctly or, when the engineer identifies that the filters are blocked as part of their routine tests.Most chemical disinfectants are hazardous to human health but formaldehyde, in particular, poses a significant risk due not only to its properties (see Table 2) but also the manner in which it is used. It is therefore essential that the need to use this substance is carefully risk assessed, that a detailed SOP for the disinfection of the MSC is developed and that this incorporates the findings of the assessment. Table 2. Properties of formaldehydeHarmful propertiesExposure to formaldehyde causes irritation of skin, eyes, and mucous membranes. It may cause sensitization in some individuals and can cause nasopharyngeal cancer. Formaldehyde has a Maximum Exposure Limit (MEL) of 2 ppm (or 2.5 mg/mL) under the COSHH Regs. It is therefore mandatory to ensure that the exposure to formaldehyde is kept below this limit and indeed as low as practicable.Physical propertiesVapour is explosive at 7.75% (v/v) in dry air and its ignition point is 430C. It should always therefore be used in humid conditions.Chemical incompatibilitiesFormaldehyde can react with chlorine-containing compounds (HCl and NaOCl) to form bis-(chlormethyl)-ether, a known lung carcinogen. All chlorine containing compounds, such as Chloros, must therefore be kept in sealed containers if they could be exposed to formaldehyde in course of fumigation.Pro-forma risk assessment MSC1 is designed to help you balance the risks of infection to yourself, other staff in the laboratory and to the service/ test engineer, arising from the work undertaken in a particular MSC, against those associated with formaldehyde fumigation of this particular cabinet. The completed risk assessment should be affixed to the relevant MSC. Risk assessment for a microbiological safety cabinetDate of this risk assessment:  FORMTEXT  Person responsible for the work in this MSC:  FORMTEXT      Person who has undertaken this assessment:  FORMTEXT      Make:  FORMTEXT      Model:  FORMTEXT      Class:  FORMTEXT      Room number:  FORMTEXT      Building:  FORMTEXT      Identification mark/number:  FORMTEXT      MSC permanently ducted to atmosphere  FORMCHECKBOX MSC recirculates back to lab  FORMCHECKBOX MSC can be temporarily ducted to atmosphere for fumigation purposes  FORMCHECKBOX What material is handled in this cabinet?Hazard Group 2 or 3 dangerous pathogens FORMCHECKBOX Unscreened human tissues or cell cultures thereof FORMCHECKBOX Class 2 or 3 genetically modified organisms FORMCHECKBOX Human secondary cell cultures with history of safe use FORMCHECKBOX Screened human tissues or cell cultures thereof FORMCHECKBOX Other: (specify):  FORMTEXT      Taking into account the work undertaken in the safety cabinet and the nature of any pathogen/ GMO that may be present, describe the preferred disinfection process for each of the following:Significant spillage in cabinet (the criteria for  significant should be specified in the Local Code of Practice)Airflow and filter integrity tests onlyOperator protection factor test and filter integrity test onlyFilter changeOther maintenanceTopical disinfection  FORMCHECKBOX  Fumigation  FORMCHECKBOX Topical disinfection  FORMCHECKBOX  Fumigation  FORMCHECKBOX Topical disinfection  FORMCHECKBOX  Fumigation  FORMCHECKBOX Topical disinfection  FORMCHECKBOX  Fumigation  FORMCHECKBOX Topical disinfection  FORMCHECKBOX  Fumigation  FORMCHECKBOX Name the disinfectant(s) of choice for topical disinfection and cabinet fumigation. 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