Estrogen receptor (ESR1) fusions are recurrent drivers of endocrine-resistant metastatic breast cancer. In this seminar, Professor Chris Toseland will discuss new findings showing that ESR1 fusion proteins form nuclear condensates that remodel chromatin architecture and organise transcriptional machinery, sustaining the transcriptional programmes that drive endocrine resistance and tumour progression. His work combines advanced imaging, biophysics and genomics to uncover the mechanisms linking nuclear organisation to cancer development.
Imperiathe speaker
Professor Chris Toseland is Professor of Cancer Biophysics at the University of Sheffield, where his research focuses on how nuclear organisation coordinates gene expression, DNA repair and genome stability. His interdisciplinary work integrates single-molecule biophysics, super-resolution microscopy, biochemistry and genomics to investigate the molecular mechanisms underpinning cancer. He also serves as Head of Assay Development at Exciting Instruments and holds a Royal Society Industry Fellowship, translating single-molecule technologies into applications for drug discovery and diagnostics.